Resumen
Se presenta el caso de una mujer que ingirió 30 g de ácido valproico, entre otros psicofármacos, en una tentativa de suicidio. La intoxicación se caracterizó por el coma profundo, con hiperamoniemia (54 μmol/L) y una elevada concentración en sangre de ácido valproico (235 μg/mL). Aunque el curso clínico se complicó con una neumonía por aspiración, la paciente evolucionó favorablemente. Se discute el mecanismo por el que se produce la hiperamoniemia es ente tipo de intoxicación.
Palabras clave
á́cido valproico; hiperamoniemia
Abstract: Hyperammonemia secondary to acute intoxication with valproic acid .
We present the case of a women who ingested 30 g de valproic acid, plus other psychoactive drugs, in a suicide attempt. The intoxication was characterized by a deep coma, with hyperammonemia (54 µmol/L) and elevated blood
levels of valproic acid (235 µg/mL). Although the clinical course was complicated by pneumonia due to aspiration, the patient evolved favourably. The mechanism that produces hyperammonemia in this type of intoxication is discussed.
levels of valproic acid (235 µg/mL). Although the clinical course was complicated by pneumonia due to aspiration, the patient evolved favourably. The mechanism that produces hyperammonemia in this type of intoxication is discussed.
Key words
Valproic acid. Hyperammonemia.
